Haemodialysis monitoring system for haemodialysis machines

摘要

An improved on-line, real time hemodialysis monitoring system for hemodialysis treatment, quantitates the rate and amount of a constituent, such as urea, removed during the hemodialysis treating by measuring the constituent concentrations as a function of time in the spent dialysate effluent from a hemodialysis machine. A quantity of the spent dialysate effluent is removed from the dialysate effluent waste line periodically for testing. A urea concentration time profile can be analyzed to determine the urea removal, KT/V, URR, SRI, and normalized protein catabolic rate (nPCR) indices. The hemodialysis monitoring system preferably can obtain a dialysate sample equilibrated with the blood prior to the start of a hemodialysis treatment. In a further aspect of the hemodialysis monitoring system includes a device for conducting two-pool analysis for taking into account the constituent concentration differences in the extracellular and intracellular spaces in the hemodialysis patient during the hemodialysis treatment to determine the intercompartmental transfer coefficient KI of a patient, which allows more precise adjustment of the hemodialysis prescription for the patient.