Use of new and known lignans and neolignans as cathepsin inhibitors, for treatment of cancers, hepatic protectors, preservation of human and animal organs, Alzheimer's, and cosmetic anti-aging preparations

摘要

The use of lignans and neolignans as cathepsin inhibitors. An independent claim is also included for compounds of formula (I). [Image] A : a group of formula (i) or (ii); R 1phenyl substituted by 1 - 3 groups selected from OH and CH 3O, or a group of formula (iii) or (iv); R 5phenyl substituted by 1 - 3 groups selected from OH and CH 3O; R 2-CH 2OH; R 3HO-CH 2-CH=CH- or HC(O)-CH=CH-; R 4H or OH. [Image] ACTIVITY : Cytostatic; Hepatotropic; Antiinflammatory; Nootropic; Neuroprotective; Dermatological; Immunosuppressive. MECHANISM OF ACTION : Cathepsin inhibitors.