Cosmetic composition with anti-aging effect on the skin contains rhamnose and fucose compounds and excipients, protects hyaluronic acid against decomposition induced by free radicals

摘要

Cosmetic composition (A) contains at least one rhamnose compound (I), a fucose compound (II) and an excipient (III). ACTIVITY : Dermatological. MECHANISM OF ACTION : (I) and (II) act, respectively, on surface keratinocytes and dermal fibroblasts, particularly by inhibiting degradation, caused by free radicals, of hyaluronic acid (HA). A solution of HA (initial viscosity about 900 cp) was tested for degradation caused by free radicals generated from a system of ascorbic acid, iron and EDTA, (a) in absence of RROP (rhamnose-rich oligo- and polysaccharides) and (b) in presence of 500 Microg/ml of RROP. After 20 hours, the viscosity had fallen to about 600 cP in (a) but only to about 770 cP in (b), i.e. RROP gave 52% protection against decomposition of HA.