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Preparation of soluble molecular complexes, useful for delivering e.g. pharmaceuticals, by molecular diffusion of active agents into host molecules in presence of diffusion agent
Preparation of soluble molecular complexes, useful for delivering e.g. pharmaceuticals, by molecular diffusion of active agents into host molecules in presence of diffusion agent
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机译:可溶性分子复合物的制备,可用于例如递送。药物,通过在扩散剂存在下将活性剂分子扩散到宿主分子中
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摘要
Method for preparing soluble molecular complexes (A) that consist of at least one active substance (I), poorly soluble in aqueous medium, incorporated into one or more host molecules (II). (I) and (II) are mixed then subjected to a molecular diffusion step in which the mixture is contacted, in static mode, with a dense fluid (III) under pressure, in presence of at least one diffusion agent (IV), then (A) recovered. An independent claim is also included for (A) prepared by the new method.
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