Porphin amp; azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy amp; in vitro sterilisation

摘要

A compound of formula I: EMI ID=1.1 HE=55 WI=59 LX=769 LY=498 TI=CF PCwherein Z is CH or N; X1, X2, X3, X4, Y1, Y2, Y3 and Y4 are H or a substituent as defined on pages 4-7 of the description (where each Y group may optionally be a fused ring), and metallated forms of such compounds, e.g. having a central coordinated optionally substituted metal or metalloid element (eg Si, Ge), are characterised in that at least one (but not all four) X group is a cationic moiety comprising a tetravalent nitrogen atom. They are photosensitive and are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Pharmaceutical formulations and sterilising solutions comprising a compound of the invention are also disclosed. Such compounds may be used in photodynamictherapy to kill microorganisms (eg bacteria, mycoplasmas, yeasts, fungi and viruses) and treat infections caused by such agents.