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Inhibition of Particulate Formation in Piperacillin/Tazobactam Parenteral Combinations, using Aminocarboxylic Acid Chelating Agents
Inhibition of Particulate Formation in Piperacillin/Tazobactam Parenteral Combinations, using Aminocarboxylic Acid Chelating Agents
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机译:使用氨基羧酸螯合剂抑制哌拉西林/他唑巴坦肠胃外组合中的颗粒形成
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摘要
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
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