METHOD FOR DETECTING ESOPHAGEAL CARCINOMA AND METHOD FOR SCREENING ANTITUMORAL MATERIAL FOR ESOPHAGEAL CARCINOMA

摘要

PROBLEM TO BE SOLVED: To provide a means for detecting Esophageal carcinoma and malignancy of the carcinoma.;SOLUTION: The carcinogenesis of esophagus cells is detected by deactivation (caused by deficiency of human LRP1B, or suppression of methylation of CpG island of the gene or acetylation of histone H4 protein) of expression of human LRP1B (Lipoprotein Receptor-Related Protein 1B) in the esophagus cells as the index. And the method for screening the antitumoral material for Esophageal carcinoma comprises using the esophagus carcinogenic cell strain suppressed in expression of human LPP1B gene due to methylation of CpG island of human LRP1B gene or acetylation of histone H4 protein.;COPYRIGHT: (C)2006,JPO&NCIPI