SUSTAINED RELEASE PELLET COMPOSITION FOR ORAL ADMINISTRATION OF TAMSULOSIN HYDROCHLORIDE, TAMUSULOSIN HYDROCHLORIDE PREPARATION FOR ORAL ADMINISTRATION AND METHOD FOR PRODUCING THE SAME

摘要

PPROBLEM TO BE SOLVED: To obtain a sustained release pellet composition for oral administration of tamsulosin hydrochloride having a uniform elution rate, and to provide a method for producing the same. PSOLUTION: The sustained release pellet composition for oral administration of tamsulosin hydrochloride contains the followings (a), (b) and (c). (a) 300-1,000 pts. wt. core; (b) a primary release-adjusting layer containing 1 pt. wt. tamsulosin hydrochloride, 200-600 pts. wt. primary release-adjusting agent selected from the group consisting of a methacrylic acid-ethyl acrylate copolymer, an ethyl cellulose and a polyvinyl acetate and 0.5-3 pts. wt. releasing assistant of at least 1 kind selected from the group consisting of an alginic acid salt, microcrystalline cellulose and sodium salt of carboxymethylcellulose; and (c) a secondary release-adjusting layer containing 1-10 pts. wt. secondary release-adjusting agent selected from the group consisting of ethylcellulose, Eudragit L100 and Eudragit S100. PCOPYRIGHT: (C)2005,JPO&NCIPI