Cell regeneration for repairing cartilage defects

摘要

Dermal fibroblasts are re-differentiated chondrocytes indicating at least one characteristic. To induce redifferentiation of cells, proteoglycans is used. In some embodiments, the cell expresses the cartilage proteoglycan at least one marker. Proteoglycan aggrecan has, cells can be differentiated from fibroblasts along the chondrogenic lineage. Method of inducing cartilage development in fibroblasts has a step of culturing fibroblasts on the surface having the proteoglycan of cartilage derived from at least one of the non-perlecan. I can three-dimensional framework is applied in proteoglycans, fibroblasts are seeded. Prior to culture, fibroblasts, is brought into contact with a cytokine or growth factor cartilage formation of at least one.