How immunizing compositions and to elicit an immune response in the amyloid precursor protein on β- secretase cleavage site

摘要

The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an A²PP epitope spanning the ²-secretase cleavage site of A²PP and a method for inducing an immune response against the ²-secretase cleavage site of A²PP using this immunizing composition. The present invention is also directed to antibodies against the ²-secretase cleavage site of A²PP and their use in a method for inhibiting the formation of amyloid ².