Production method of nucleotide arrangement and the D- mannitol which mannitol -2- dehydrogenase the cord/code are done

摘要

This invention regards the production method of nucleotide arrangement and the D- mannitol which mannitol -2- dehydrogenase the cord/code are done. The living thing catalyst production method D- mannitol being known until now only possesses low rate of production on the basis of the specific activity whose mannitol -2- dehydrogenase is low from D- fructose concerning the conversion to D- mannitol. The mannitol production which is improved the nucleotide arrangement which the mannitol -2- dehydrogenase which possesses a higher specific activity the cord/code is done by easily, can be achieved. In the microbe the mannitol production which by the fact that playback system concerning the restoration equivalence formic acid dehydrogenase introduction and/or by making strengthen is achieved, especially is raised can be achieved.