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1-oxa-3-aza-dibenzoazulene as an inhibitor of tumor necrosis factor production and intermediate for its production

机译:1-氧杂-3-氮杂-二苯并azulene作为肿瘤坏死因子产生的抑制剂及其产生的中间体

摘要

The present invention relates to derivatives of 1-oxa-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumour necrosis factor-alpha (TNF-alpha) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
机译:本发明涉及1-氧杂-3-氮杂-二苯并azulene类的衍生物,其药理学上可接受的盐和溶剂化物,涉及其制备方法和中间体,以及其抗炎作用,特别是对肿瘤坏死因子的抑制作用。 -α(TNF-α)的产生和白介素1(IL-1)的产生及其镇痛作用的抑制作用。

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