How to increase the contractility heart, cardiomyocytes or myocardial

摘要

A method of increasing the contractility of a heart, a heart muscle or cells of a heart muscle i by administering an agent capable of binding to a phosducin binding site of Gbetagamma is provided. Said phosducin binding site is preferably a binding site of N-terminal truncated phosducin. Further, methods of identifying compounds capable of increasing the contractility of a heart muscle and methods of identifying compounds capable of inhibiting Gbetagamma-mediated processes are provided.