首页>
外国专利>
Prediction method of drug susceptibility using the factor is selected and the selection method specified drug sensitivity factor
Prediction method of drug susceptibility using the factor is selected and the selection method specified drug sensitivity factor
展开▼
机译:选择使用该因子的药物敏感性预测方法,并选择指定药物敏感性因子的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Based on drug sensitivity data and extensive gene expression data, a model was constructed by multivariate analysis with the partial least squares method type 1. Further, the model was optimized using modeling power and genetic algorithm. Thereby, the degree of contribution of the respective genes to drug sensitivity was determined to select genes with a high degree of contribution. In addition, the levels of gene expression in specimens were analyzed, and then the drug sensitivity was predicted based on the model. The predicted values agreed well with those drug sensitivity values determined experimentally. The drug sensitivity-predicting method provided by the present invention enables assessment of the effectiveness of a drug prior to administration using small quantities of specimens associated with diseases such as cancer. Since this enables the selection of the most suitable drug for each patient, the present invention is very useful in improving a patient's quality of life (QOL).
展开▼