How to modulate it and molecular interaction site of the 23S ribosomal RNA

摘要

Polynucleotide comprising a molecular interaction site of 23S rRNA having a second particular structure is provided. The method used to reality and virtual screening combinatorial libraries of compounds that bind to it, such polynucleotides are also provided. By contacting a compound identified by the real or screening such virtual, prokaryotic cells containing or 23S rRNA, methods of modulating the activity of the 23S rRNA are also provided. [Selection] Figure Figure 1