System for the development of agents that block DNA replication Yersinia pestis and Pseudomonas aeruginosa (YERSINIAPESTIS) of (PSEUDOMONASAERUGINOSA)

摘要

nucleic acid molecule of Pseudomonas aeruginosa and Yersinia pestis encoding dnaE, holA, holB, holC, holD, holE, dnaX, dnaN, SSB, dnaG, the dnaQ protein is provided. The encoded protein is also provided. Protein and the nucleic acid molecules are useful sequencing of compounds that modulate the function of the replicase or polymerase, to thereby reconstruct the replicase and polymerase for amplification and screening.