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Enzyme crystal structure and use of the crystal structure
Enzyme crystal structure and use of the crystal structure
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机译:酶的晶体结构及其用途
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摘要
The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors. These modulators may be used to treat diseases of cell proliferation, e.g. cancer.
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