Cell lines and methods for the replication of rabies virus and its quantitative detection

摘要

PCT No. PCT/EP96/00424 Sec. 371 Date Sep. 12, 1997 Sec. 102(e) Date Sep. 12, 1997 PCT Filed Jan. 30, 1996 PCT Pub. No. WO96/30499 PCT Pub. Date Oct. 3, 1996A permanent cell line PH2, and a process for replication of rabies viruses which have a cytopathic effect (CPE) is claimed. The process comprises: infecting the PH2 cell line with the virus to be replicated; incubating the cells; and isolating and purifying virus particles after they have reached a sufficiently high titer.