Phase transition colloids as ultrasound contrast agents

摘要

(57) and the liquid contrast enhancing agents in [summary] ultrasonic diagnostic method, - colloidal dispersion in the form of liquid type, ie consists of a micro-emulsion or emulsion, is the dispersed liquid phase, of the animal to be a contrast It is a liquid having a boiling point below body temperature, when administered to an animal, the dispersion liquid, the dispersion liquid undergoes a phase change to spherical bubble or bubbles dispersed gas a stronger echo ability. Of 1000nm or less, the particle size is very stable Typically, the dispersed phase liquid state makes it possible to produce emulsions that are pharmaceutically acceptable. A gaseous state at body temperature, to generate microbubbles with high capacity of echo 10,000nm diameter typically less than, the microbubbles are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and dosage form of intrauterine administration, method of administration, and are disclosed imaging techniques.