Anorexia nervosa or lifestyle-related disease drug and screening method thereof

摘要

The present invention provides a novel lifestyle-related disease or anorexia remedy with good food intake control and a screening method thereof. Specifically, GPCR expressed in the hypothalamus, an anorexia remedy containing a substance that suppresses the expression or function of GPRC5D as an active ingredient, and lifestyle-related disease treatment containing a substance that enhances the expression or function of the receptor as an active ingredient A screening system comprising a series of co-expression systems of drugs, GPRC5D and various G proteins, and a screening method for substances having therapeutic activity against anorexia or lifestyle-related diseases by using the screening system are provided.