Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT 1B/1D ligands

摘要

Amide and urea derivatives of the formula I R¹—(CH₂)_n—(Y)_q-(Z)_r-CO—NH—R²   (I) in which R¹, n, Y, q, Z, r and R² have the meanings indicated in claim 1, are potent 5-HT_1B/1D antagonists and exhibit 5-HT reuptake-inhibiting actions and are suitable for the treatment and prophylaxis of anxiety states, depressions, schizophrenia, compulsive ideas, tardive dyskinesias, learning disorders, age-dependent memory disorders, for positively affecting obsessive-compulsive behaviour (OCD), and also for the treatment and for the control of the sequelae of cerebral infarcts such as stroke and cerebral ischaemias.