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Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
Interspersed repetitive element RNAs as substrates, inhibitors and delivery vehicles for RNAi
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机译:散布的重复元件RNA作为RNAi的底物,抑制剂和传递载体
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摘要
The present invention provides methods for identifying druggable targets in assays that feature compositions, cells and/or organisms having interspersed repetitive element (IRE) RNAs and an RNA interference (RNAi) pathway. Methods for identifying therapeutic agents and creating vaccines are also featured. The invention further provides methods for inhibiting RNAi involving IRE RNAs or inhibitory derivatives thereof. The invention also provides compositions for delivering siRNA and miRNA molecules derived from IRE loci and methods of use thereof. Therapeutic methods are also featured.
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