Variants of human kallikrein-2 and kallikrein-3 and uses thereof

摘要

The present invention pertains to the field of biology, genetics and medicine. It particularly pertains to new methods for detecting, characterising and/or treating cancers, particularly prostate cancer. The invention also pertains to methods for identifying or screening for compounds that exhibit activity in these diseases. The invention also relates to the compounds, genes, cells, plasmids or compositions that can be used to carry out the methods herein above. The invention particularly describes the role in these diseases of variants of human kallikrein 2 and human kallikrein 3, also known by the name PSA, and their use as therapeutic, diagnostic or experimental targets.