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Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression
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机译:具有驱动抗原表达的哺乳动物cd80 / cd86基因启动子的核酸疫苗组合物
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摘要
Polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter derived from a gene encoding a co-stimulatory molecule are provided. The polynucleotides may also encode adjuvants. Compositions comprising at least one immunizing agent and at least one cytokine that enhance dendritic cell stimulation and/or survival are also provided. Methods for eliciting an immune response against the immunizing agent are also provided. The method includes the steps of administering the polynucleotides and, optionally, co-administering an adjuvant.
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