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Reduction of zinc-induced neurotoxic injury by blockade of nitric oxide synthesis
Reduction of zinc-induced neurotoxic injury by blockade of nitric oxide synthesis
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机译:通过阻断一氧化氮合成减少锌诱导的神经毒性损伤
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摘要
The present invention provides methods of inhibiting release of zinc from neurons and of preventing zinc-mediated brain injury. Also provided are methods of improving cerebral blood flow while preventing zinc-mediated brain injury. Inhibitors of or activators of nitric oxide synthases modulate nitric oxide synthesis to reduce nitric oxide-induced release of neurotoxic amounts of zinc, thereby reducing zinc-mediated neuronal injury after brain trauma.
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