Novel virus proliferaton inhibition/virucidal method and novel pyradine nucleotide/pyradine nucleoside analogue

摘要

chemistry chemdraw file chemistry mol file ;wherein each of R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹ and A has the same meaning as given in the specification. ;The present invention relates to a method for exhibiting a virus growth-inhibiting effect and/or a virucidal effect, in which pyrazine nucleotide analog 2 and pyrazine nucleoside analog 3z are subjected to biotransformation, decomposed and then phosphorylated, so that they become a pyrazine nucleotide analog 1b exhibiting the aforementioned effect. This method is useful as a method for treating virus infections. Moreover, the pyrazine carboxamide analog or a salt thereof of the present invention is useful as an agent for preventing or treating virus infections.