首页>
外国专利>
Anti-tumor effects of prostage Carcinoma Tumor Antigen-1
Anti-tumor effects of prostage Carcinoma Tumor Antigen-1
展开▼
机译:前列腺癌肿瘤抗原1的抗肿瘤作用
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to methods of inhibiting the proliferation and/or metastasis of a cancer cell by administering, to the cancer cell, a molecule which increases, in the cell or at the cell surface, the amount of a Bivalent Prostate Carcinoma Tumor Antigen-1 (B-PCTA-1) protein (referred to as bivalent because it comprises both carbohydrate recognition domains (CRDs)). It is based, at least in part, on the discovery that increased expression of the full-length open reading frame of the PCTA-1 gene suppressed proliferation of tumor cells in soft agar (a characteristic associated with malignancy and tumor metastasis), whereas increased expression of a PCTA-1 gene lacking the second CRD-encoding region had the opposite effect, increasing the anchorage-independent proliferation of the tumor cells.
展开▼