Compounds capable of binding to proteins constituting or associated with cytoskeletal elements, and their applications for the manufacture of medicaments

摘要

The invention concerns the use of steroids and non-toxic compounds, capable of crossing the blood brain barrier characterized in that they are capable of binding the same site as pregnenolone on proteins constituting or associated with elements of the cytoskeleton and of displacing the MAP₂-bound pregnenolone, and of influencing the assembling and stabilization of microtubules. The invention is particularly useful for treating the nervous system, for fighting against ageing of cells containing MAP₅, and for treating cancers.