Crystals and structures of SARS-CoV main protease

摘要

The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of SARS-CoV main protease and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator, mutants of SARS M^pro, SARS M^pro crystals, and compounds and compositions that affect SARS M^pro activity.