System and method for scoring peptide mass fingerprinting

摘要

The present disclosure relates to a system and method for scoring peptide mass fingerprinting. In one exemplary embodiment, a method for scoring peptide mass fingerprinting may comprise the steps of: providing a first list of peptide masses and a second list of peptide masses; defining a match between the first list of peptide masses and the second list of peptide masses based on one or more match components; calculating a first probability for observing the match based on a first hypothesis that the first list of peptide masses originates from a protein sample from which the second list of peptide masses originates; calculating a second probability for observing the match based on a second hypothesis that the first list of peptide masses does not originate from the protein sample from which the second list of peptide masses originates; and scoring the match between the first list of peptide masses and the second list of peptide masses based at least in part on a ratio between the first probability and the second probability.