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Use of indanoyl amide to stimulate secondary metabolism in Taxus sp.
Use of indanoyl amide to stimulate secondary metabolism in Taxus sp.
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机译:使用茚满酰酰胺刺激红豆杉第二代谢。
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摘要
The invention is directed to a method for the production of taxanes by culturing suspension cells of Taxus sp. in a nutrient medium that comprises an indanoyl amino acid. The indanoyl amino acid may be added in batch mode or in a feed stream at any time of the culturing. In particular, synthetic compounds 6-Ethyl-indanoyl-isoleucine, 6-Bromoindanoyl isoleucine and 1-oxo-indane-carboxy-(L)-Isoleucine-methyl ester amide (1-OII) have been found to increase taxane production from Taxus cell cultures.
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