The present invention provides systems and methods for imaging, diagnosing and treating an eye of a patient. In one embodiment, a system (100) includes an image source arranged to direct an image posteriorly through the eye optical tissues and onto the retina, and a wavefront sensor (140). The wavefront sensor, comprising a lenslet array (170) and a CMOS imaging device, is oriented to sense the image transmitted anteriorly by the optical tissue. A processor may be coupled to the wavefront sensor for processing the image. In some embodiments, the CMOS imaging device comprises a CMOS camera having a dynamic range that is at least about 100 db, to provide the ability to image high contrasting images, such as a series of bright lights on a dark background as may be produced when imaging the eye.
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