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DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides
DNA polymerase having ability to reduce innate selective discrimination against fluorescent dye-labeled dideoxynucleotides
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机译:具有减少对荧光染料标记的双脱氧核苷酸的先天选择性歧视的能力的DNA聚合酶
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摘要
The invention relates to genetic modification of DNA polymerase to reduce innate selective sequence-related discrimination against incorporation of fluorescent dye-labeled ddCTP and ddATP in the enzymatic reaction for preparation of samples for automated fluorescent dye-labeled terminator DNA sequencing. The modified DNA polymerases are more resistant to heat inactivation and are more effective in dideoxynucleotide incorporation than current DNA polymerases.
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