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Novel polyol macrolide antitumor-antibiotics from the novel actinomycete strain CNQ140
Novel polyol macrolide antitumor-antibiotics from the novel actinomycete strain CNQ140
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机译:新型放线菌菌株CNQ140的新型多元醇大环内酯类抗肿瘤抗生素
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摘要
A novel family of cyclic polyene natural products isolated from marine actinomycete strain CNQ140 is provided. This novel strain of actinomycetes was obtained from a previously unstudied population of marine actinomycetes that reside in sediments off La Jolla, Calif. Compounds derived from strain CNQ140 have been characterized as having a cyclic polyene-polyol structure; a molecular weight from about 996 to about 1010 in the core ring structure; and at least 58 carbons and at least 14 oxygens. The invention compounds have antitumor and/or anti-microbial activity.
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