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Method of screening for pharmaceuticals by detecting cross talk between intracellular signals and intranuclear receptors
Method of screening for pharmaceuticals by detecting cross talk between intracellular signals and intranuclear receptors
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机译:通过检测细胞内信号与核内受体之间的串扰来筛选药物的方法
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摘要
Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-β super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.
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