embedded imageor pharmaceutically acceptable salt forms thereof, wherein A, B, C, D, R1, and R2 are defined in the present specification, which are useful as metalloprotease, TNF-α, and/or aggrecanase inhibitors."/> Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)
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Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE)

机译:双环内酰胺衍生物作为基质金属蛋白酶和/或TNF-α转化酶(TACE)的抑制剂

摘要

The present application describes novel bicyclic lactam derivatives of formula I: embedded imageor pharmaceutically acceptable salt forms thereof, wherein A, B, C, D, R1, and R2 are defined in the present specification, which are useful as metalloprotease, TNF-α, and/or aggrecanase inhibitors.
机译:本申请描述了式I的新型双环内酰胺衍生物: <图像alt =“嵌入式图像” file =“ US06884806-20050426-C00001.GIF” he =“ 20.15mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 50.80mm“ /> 或其药学上可接受的盐形式,其中在本说明书中定义了A,B,C,D,R 1 和R 2 ,它们可用作金属蛋白酶,TNF -α和/或聚集蛋白聚糖酶抑制剂。

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