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T cell binding ligand peptides and method of inducing a cellular immune response
T cell binding ligand peptides and method of inducing a cellular immune response
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机译:T细胞结合配体肽和诱导细胞免疫应答的方法
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摘要
The present invention is based, in part, on the discovery that a modified version of Peptide G (Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO:2) obtained by replacing Asn with Asp to form Peptide G′ (Asp Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile—SEQ ID NO: 1) overcomes the long range stabilization problem of the peptide conjugates and, quite surprisingly, also enhances the immune response, particularly the CD4 related (cell mediated) response, of conjugated peptides (L.E.A.P.S. constructs) as previously described.
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机译:本发明部分地基于以下发现:通过用Asp代替Asn而获得的肽G的修饰形式(Asn Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile-SEQ ID NO:2)。肽G'(Asp Gly Gln Glu Glu Lys Ala Gly Val Val Ser Thr Gly Leu Ile-SEQ ID NO:1)克服了肽缀合物的长期稳定问题,并且非常令人惊讶的是,还增强了免疫反应,特别是CD4如前所述与偶联肽(LEAPS构建体)相关的(细胞介导的)应答。
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