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5-thio-β-D-xylopryanoside derivatives, preparation, method, pharmaceutical compositions containing them and their therapeutic use

机译:5-硫代-β-D-吡喃龙脑苷衍生物,制剂,方法,含有它们的药物组合物及其治疗用途

摘要

The present invention relates to novel compounds of formula (I): embedded imagein which:R1, R2 and R3, which are identical or different, are each independently: a (C1-C6)alkyl group,a pyridinyl group ora group —CH2—NR4R5, in which R4 and R5 are each independently a hydrogen atom or a (C1-C4)alkyl group, or alternatively R4 and R5 form, with the nitrogen atom to which they are bonded, a pyrrolidinyl, piperidinyl, hexahydroazepinyl, morpholinyl or piperazinyl group,with the proviso that at least one of the substituents R1, R2 and R3 is other than a (C1-C6)alkyl group,and their salts, solvates and hydrates, especially those which are pharmaceutically acceptable.;These compounds are useful particularly for the treatment of disorders of the venous circulation.
机译:本发明涉及式(I)的新化合物: <图像alt =“嵌入式图像” file =“ US06927209-20050809-C00001.GIF” he =“ 38.18mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 69.68mm“ /> 其中: R 1 ,R 2 和R < Sub> 3 相同或不同,分别独立: a(C 1 -C 6 )烷基, 吡啶基或 基团-CH < Sub> 2 —NR 4 R 5 ,其中R 4 和R 5 独立地是氢原子或(C 1 -C 4 )烷基,或者是R 4 和R 5 与它们键合的氮原子形成吡咯烷基,哌啶基,六氢a庚啶基,吗啉基或哌嗪基,前提是取代基R 1 ,R 2 和R 3 中的至少一个不是(C 1 < / Sub> -C 6 )烷基,及其盐,溶剂化物和水合物,特别是药学上可接受的盐。 ;这些化合物尤其可用于治疗静脉循环障碍。

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