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Genes for human telomerase reverse transcriptase and telomerase variants

机译：人类端粒酶逆转录酶和端粒酶变体的基因

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摘要

The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.

机译：本发明涉及新型端粒酶核酸和氨基酸。特别地，本发明涉及编码各种端粒酶蛋白亚基和基序的核酸和氨基酸序列，包括 Euplotes aediculatus 的123kDa和43kDa端粒酶蛋白亚基，以及来自的相关序列。 >裂殖酵母，酿酒酵母序列和人类端粒酶。本发明还涉及包含这些端粒酶蛋白亚基的多肽，以及包含这些亚基的功能性多肽和核糖核蛋白。 展开▼

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公开/公告号US6927285B2

专利类型

公开/公告日2005-08-09

原文格式PDF

申请/专利权人 THOMAS R. CECH;JOACHIM LINGNER;TORU NAKAMURA;KAREN B. CHAPMAN;GREGG B. MORIN;CALVIN B. HARLEY;WILLIAM H. ANDREWS;
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申请/专利号US19990438486

发明设计人 KAREN B. CHAPMAN;WILLIAM H. ANDREWS;TORU NAKAMURA;CALVIN B. HARLEY;THOMAS R. CECH;GREGG B. MORIN;JOACHIM LINGNER;
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申请日1999-11-12

分类号C07H21/04;C12N9/12;C12N1/20;C12N15/00;C07K1/00;

国家 US

入库时间 2022-08-21 22:19:28

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3. Protein isolated and htrt preparation, htrt protein fragment, human telomerase, isolated polynucleotide, expression vector, cell, non-human organism, isolated or recombinant antibody, processes for determining whether a compound or treatment is a modulator of an activity or expression of htrt, if a test compound is a modulator of a telomerase reverse transcriptase activity, to identify a compound that modulates htrt activity, to prepare recombinant telomerase, to detect a htrt people product in a sample and the presence of at least one telomerase positive human cell in a biological sample, to diagnose a telomerase-related condition in a patient and cancer to provide a prognosis for a cancer patient, to monitor the ability of an anti-cancer treatment, to reduce the ability proliferation of cancer cells in a patient, to increase the proliferative capacity of a vertebrate cell, to treat a condition associated with a high level of telomerase activity within a cell, to isolate a selected nu [P] . BR9712254A . 2000-01-18

机译：分离的蛋白和htrt制剂，htrt蛋白片段，人类端粒酶，分离的多核苷酸，表达载体，细胞，非人类有机体，分离的或重组抗体，确定化合物或治疗是否是htrt活性或表达调节剂的过程，如果受试化合物是端粒酶逆转录酶活性的调节剂，则鉴定可调节htrt活性的化合物，制备重组端粒酶，检测样品中的htrt人产物以及是否存在至少一个端粒酶阳性人类细胞生物学样品，以诊断患者和癌症中的端粒酶相关病症，为癌症患者提供预后，以监测抗癌治疗的能力，减少患者癌细胞的增殖能力，从而增加癌症患者的预后。脊椎动物细胞的增殖能力，用于治疗与细胞内端粒酶活性高水平有关的疾病，分离选定的核酸

4. Polynucleotide encoding Human Telomerase reverse transcriptase and method for preparing Human Telomerase reverse transcriptase in E. coli using the same [P] . 韩国专利： KR100779055B1 . 2007-11-28

机译：编码人端粒酶逆转录酶的多核苷酸和使用该多核苷酸制备大肠杆菌中人端粒酶逆转录酶的方法

5. Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity [P] . 美国专利： US7517971B1 . 2009-04-14

机译：缺乏端粒酶催化活性的人端粒酶逆转录酶突变蛋白

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6. 人类端粒酶逆转录酶基因的原核表达及其表达产物抗体的制备 [A] . 尚世彤 . 2002