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As development of the pituitary gland in the Progeny of Females treated with Prenadas Therapy with growth hormone Releasing Hormone

机译:随着生长激素释放激素对Prenadas治疗的雌性子代垂体的发展

摘要

The long-term growth and development of infant fi was accelerated by injecting growth antiprotein hormone (GH) fermentation hormone (adnc) into the body of 16 day pregnant mothers by electrolysis. Parents are much older than a week, and differences persistTen weeks old With the steady increase of this growth rate, the plasma concentration of immune system-i is greatly increased. The pituitary gland of the offspring is much heavier and contains increased element phosphorus (the cell that produces GH) and lactate phosphorus (the cell that secretes).It shows that the blood vessels of cells have changed These unique findings suggest that GHRH is becoming more and more apparent in preterm mothers, with the result that it promotes intergenerational growth by altering the development of the pituitary gland in the uterus. Requirement 1: a method for changing the pituitary lineage of the offspring of a female fetus, including: releasing the nucleic acid expression structure in the cell of the female fetus; completing the release before or during pregnancy; The construction of nucleic acid expression includes a driver and a nucleic acid sequence.and an untranslated region 3; and the release is completed under conditions where the expression of the nucleic acid sequence results in the change of lineage of the pituitary of the progeny.
机译:通过电解将生长抗蛋白激素(GH)发酵激素(adnc)注入16天怀孕的母亲体内,可以促进婴儿fi的长期生长和发育。父母的年龄比一周大得多,而且差异持续十周大。随着这种生长速度的稳定增长,免疫系统-i的血浆浓度大大增加。后代的垂体重得多,并含有增加的元素磷(产生GH的细胞)和乳酸磷(分泌的细胞)。这表明细胞的血管已经改变。这些独特的发现表明GHRH正在变得越来越多。在早产母亲中更为明显,其结果是通过改变子宫垂体的发育来促进代际生长。要求1:改变雌性胎儿后代垂体谱系的方法,包括:在雌性胎儿的细胞中释放核酸表达结构;在怀孕之前或期间完成释放;核酸表达的构建包括驱动子和核酸序列以及非翻译区3;并且在核酸序列的表达导致后代的垂体谱系改变的条件下完成释放。

著录项

  • 公开/公告号AR038816A1

    专利类型

  • 公开/公告日2005-01-26

    原文格式PDF

  • 申请/专利权人 BAYLOR COLLEGE OF MEDICINE;

    申请/专利号AR2003P100375

  • 发明设计人 DRAGHIA-AKLI RUXANDRA;KHAN AMIR.;

    申请日2003-02-06

  • 分类号A61K48/00;A61P5/02;A61P5/06;C12N5/10;C12N15/87;C12N15/86;C12N15/16;C07K14/575;C07K14/60;C07K14/61;C07K105/00;

  • 国家 AR

  • 入库时间 2022-08-21 22:18:53

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