Combinations of drugs containing Heterocyclic compounds and an anticholinergic Agent. Aerosol inhalation

摘要

1. Based on the pharmaceutical composition of No. 1 and No. 2 heterocyclic compounds, the preparation procedure and the procedure for the treatment of respiratory diseases. 1. Characteristic 1: a drug containing one or more substances, preferably a formula salt (1), wherein X - refers to a single anion negatively loaded, preferably a specific anion of substances such as chloride, bromine, iodine, sulfate, phosphate, methane sulfate, nitrate, maleic acid, acetic acid, citrate, etc, Fumigation, Tartra, oxalato, succenato, Benzoato, and p-toluenyl-aromatic acid, plus one or more,Preferably a compound (2) in a common formula, which may mean: R1 hydrogen, methyl, ethyl, n-butilo, i-butilo, phenyl, 2-Ethylphenyl, 2-i-propilphenyl, bencilo, 4-piridio, 2-piridiilo, Co fenilo, CN orWith R2, a butileno bridge or a bentileno bridge; R2, hydrogen, methyl, ethyl or with R1, a butene or pentene bridge; or with R13, a simple link or butene bridge; R3, hydrogen; R4 methoxi; R5, cyclohexane, phenyl, 3-methoxyphenyl, 4-methoxy, 3-carboxifenifonilo, 4-carboxifenilo, CN, - COOH, coome, 3, 5-dichloro-pyridine-4-il, 4-pyridine or 4-pyridine-n-oxide; a is oxygen or - CH2 -;B is oxygen, or a C (R12) (R13) - o-ch (R15) - CH (R17) group;D is a slave from - ch2-ch2--CH (Ph) -CH2-,- er...-CO-CH2...-CH=CH---C (Ph) 3DCH--C (R18) (R19) -X--C (R19a) 3DY--CSC - or phenyl; R12 is hydrogen, methyl, ethyl, propyl, phenyl or CH2 Corx; R13 is hydrogen or,With R2, a simple link or butene bridge; R15 is hydrogen, or a simple link with R17; R17 is hydrogen, or a simple link with R15; R18 is hydrogen or methyl; R19 is hydrogen, methyl, benzene or CN; R19 A is hydrogen, methyl or benzene; Rx is hydroxy, etoxi, beniloxi, 2-feniletoxi, 4-methyl-piperazin-1-il, 4-phenylpyridine-1-il, n-tetrahydro-isoquinol, nh-phenyl, nh-phenyl, nh-phenyl, nh-ch2 - (4-methoxyphenyl),-Nh-ch2 - (4-fluoride)-Nh-ch2 - (4-chlorophenyl),-Nh-ch2 - (2-chlorophenyl),-NH- (3-pyridyl),-NH-CH2- (2-pyridyl),-NH-CH2- (3-pyridyl),-NH-CH2- (4-piridilo)-NH - (3,5-dichloropyridine-4-il) or - NH - (2-pyridine);X is -CH2.- yes.That's what it means.It is ch, CCN, ccooet or chconh, which may be in the form of a single optical isomer, their mixture or racemate, and their salt form, plus acid, which is pharmaceutically tolerable, may be in the form of solution or hydrate, And finally an acceptable assistant pharmacist