Diagnosis and Treatment of glaucoma and methods to discover new therapeutic agents based on the Signalling Pathway of Wnt / Ca2 -

摘要

Claim 1: a method to Diagnose glaucoma in a patient, the method comprising the following steps: (a) obtaining a sample of the patient; or (b) to detect the level of bioactivity component of Wnt / Ca2 + Pathway, a product of Frizzled Related Protein gene The Wnt / Ca2 + Pathway.A FRP or via the Wnt / Ca2 + and (c) comparing the level of bioactivity or component of the Wnt / Ca2 + Pathway, Gene product of Frizzled Related Protein or FRP of the Wnt / Ca2 + level in a normal Sample, where a level of bioactivity Component or Aberrant The Path of The Wnt / Ca2 +,A Gene product of Frizzled Related Protein or FRP of the Wnt / Ca2 + Pathway is indicative of a State glaucomatous.Claim 7: a method for the treatment of glaucoma in a patient, the method comprises administering to the patient a composition comprising a therapeutically effective amount of a compound that modulates the level of bioactivity or a component of the Wnt / Ca2 + Pathway, a pro Duct of the Frizzled Gene related to Wnt / Ca2 + Pathway or FRP of the Wnt / Ca2 + Pathway.Claim 8: The Method according to claim 7, wherein the compound is selected from the group consisting of a Protein, a Peptide, a peptidomimetic Small Molecule or a nucleic acid.