'Derivatives' 9A - substituted N - (n '- carbamoyl - gamma Aminopropyl, 9a) - N - (n' - tiocarbamoil - gamma Aminopropyl, 9) - N - n '- (A - cianoetil) - n' - carbamoyl. Gamma Aminopropyl 9 - 9 - deoxo Dihydro 9A - aza - 9th - homoeritromicina and 5 - or - deoxo desominil - 9 - 9 - 9 - dihydro - aza -

摘要

N '- substituted derivatives 9a N - (n' - carbamoyl - range - Aminopropyl, 9a) - N - (n '- tiocarbamoil - range - Aminopropyl, 9a) - N - [n' - (beta cianoetil) - n '- carbamoyl - range - Aminopropyl and 9A - N - [] n' - (beta cianoetil) - n '- tiocarbamoil - range - Aminopropyl] deoxo - 9 - 9 - dihydro - 9A - aza - 9th - homoeritromicina and 5 - or - desosaminil - 9 - deoxo - 9 - dihydro - 9A - aza - 9th - homoeritronolida,New semisynthetic macrolide antibiotics of azalidas Series of General formula (1), wherein R represents H or an cladinosilo, R1 represents H or a beta cianoetilo, R2 represents an isopropyl - naphthyl Group, 1, 2 - naphthyl benzyl, phenyl, 2 - (3 - trilfuorometil), fenilpropilo, BE Ta feniletilo, Ethoxycarbonyl Methyl, 1 - (1-naphthyl) ethyl trimetoxifenilo 3,4,5 - 2.4 - and diclorofenilo,And x represents o and S, and its acceptable Addition salts with inorganic or organic acids, Process for the preparation of pharmaceutical compositions, and use of compositions for the treatment of bacterial infections.