Phenylalanine derivatives as inhibitors of the dipeptidilpeptidasa for the Treatment or prevention of Diabetes

摘要

This refers to phenylalanine derivatives which are inhibitors of the Enzyme dipeptidilpeptidasa - IV (known as "inhibitors of DP IV") and which are useful in the Treatment or prevention of diseases in which the dipeptidilpeptidasa IV Enzyme is involved, such as di ABETES and particularly Type 2 diabetes.It also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the Prevention or treatment of such diseases in which the Enzyme is involved dipeptidilpeptidasa - IV.Claim 1: a compound of Structural formula (1), in which X is CH2 CHF, and CF2, S; W is CH2 CHF, or CF2; R2 is selected from the group consisting of; Methyl, Ethyl, CH2 COOH, - ciclopropilo, Coome, cooet, conhme, conme2, CONH2, conhet, - ilcarbonilo pyrrolidin-3-yl conmech2ph, - 1, - 1 - ilcar azetidin Bonilo fluoroazetidin - 1 -, 2 - (4 - ilcarbonilo, ilcarbonilo,And (tetrazol [- 5 - il) amino] carbonyl; and R4 is selected from the group consisting of 4 - fluorofenilo, 2,4 - difluorofenilo, 3,4 - difluorofenilo, 2-chlorophenyl - fluorofenilo, 2, 3 (metolsulfonol phenyl) - 3 - (ethoxycarbonyl) phenyl carboxifenilo - 3, 3 - (Aminocarbonyl) phenyl, 3 - [(tert butylamino) carbonyl] phenyl [3 - (phenylamino) carbonyl] phenyl [3 - (2 - ilamino thiazole) carbonyl] phenyl3 - [(tetrazol - 5 - ilamino) carbonyl] phenyl [[3 - (trifluoromethyl) sulfonyl] amino] phenyl (tetrazol - 3 - 5 - il) phenyl 4-fluoro-3 - (tetrazol - 5 - il) phenyl 2-fluoro-5 - (tetrazol - 5 - phenyl (IL), 3 - 5 - oxo 4,5-dihydro - 1,2,4 - Oxadiazoles - 3 - il) phenyl 4-fluoro-3 - (5 - oxo - Oxadiazoles 4,5-dihydro - 1,2,4 - phenyl - 3 - il), 3 - (5 - oxo - 4.5 - d Ihidro - 1,3,4-oxadiazol-2 il phenyl) - 3 - (5 - oxo - 4,5 dihydro - 1h-1,2,4-triazole il, phenyl - 3 - 3 - (1,3),4 - phenyl - 2 - Oxadiazoles, 3 (IL) - 1,2,4-triazole - 3 - il) phenyl 3 - [5 - (trifluoromethyl) - 1,2,4-triazole il] - phenyl - 3, 3 - (5 - ethoxy - 3 - The 1,2,4-triazole - phenyl - 3 - pyridin), ILO 6 - fluoro - pyridin - 3 - 6 - metoxipiridin ILO, IL - 3 -, 6 -, oxo - 1.6 - dihidropiridin - ILO - 3, 1 - methyl - 4 - oxo - 1.6 - dihidropiridin - ILO - 3, 6 - 1 - ethyl - oxo - 1,6 Dihydro - i 5bromo pyridin - 3, 6 - 1 - methyl - 3 - oxo - 1.6 - dihidropiridin - ILO, imidazo [1,2-a] pyridin - 6-yl [1,2,,4] triazolo [4,3-a] pyridin - 6-yl, 3 - (trifluoromethyl) [1,2,4] triazolo [4,3-a] pyridin - 6-yl, 3 - oxo 2,3 dihydro [1,2,4] triazolo [4,3-a] pyridin - 6-yl, 2 - methyl - 3 - oxo - 2,3 dihydro [1,2,4] triazolo [4,3-a] pyridin - 6 - 4 - 6 - aminoquinazolin ILO, ILO, 2 - (Acetylamino) imidazo [1,2-a] pyridin - il - 6, 3 - aminoimidazo [1,2-a] pyridin-3 - 3 - 6 - ILO, carboxipirazolo [1,5-a] pyridin-3 ILO - 5 - 6 - 5 - bromo -, oxo - 1.6 - dihidropiridin - ilo [1,2, 3,4] triazolo [1,5-a] pyridin - 6-yl [1,2,4] triazolo [1,5-a] pyridin - 7 - ILO and pyrazolo [1,5-a] pyrimidin-5-yl.