Ester of 2 '- C' - methyl - 3 - or - L - valine of ribofuranosilcitidina for treating Flaviviridae Infections, their use in the manufacture of medicaments and Methods for treating Flaviviridae infections

摘要

A compound (1) having a formula structure,Or alternatively, in a pharmaceutically acceptable vehicle, to produce or produce pharmaceutically acceptable salts for the treatment of infected or long-lived persons. In a particular use, the salt acceptable for a drug is a hydrochloride in formula (2),in another embodiment the pharmaceutically acceptable salt of formula (1) is selected from tosylate, methanesulfonate, acetate, citrate, malonate, tartarate, succinate, benzoate, ascorbate, alpha-acetoglutarate and alpha-glycerophosphate, format, fumarate, propionate, glycolate, lactate , pyruvate, oxalate, maleate, salicylate, sulfate, sulfonate, nitrate, bicarbonate, hydrobromate, hydrobromide, hydroiodide, carbonate, and phosphoric acid salts. A compound of formula (1) or (2),Among them, 5 '- hydroxy is replaced by a 5' - or, R is phosphate; stable phosphate production; acid; aspha sulfuric acid ester, including asphalt or nitroso sulfuric acid ester, including methane sulfate and benzene, where it can replace phenyl; a fat; an amino acid; a hydrate carbon; A peptide, cholesterol, or other acceptable drug, when taken on site,It can provide a compound in which R is an independent h or phosphate. 1. Pharmaceutical ingredients, including the effective quantity of a formula (1) or formula (2), or an acceptable salt of a drug for treating flash infection in a vehicle acceptable to the drug. Compounds of formula (1) or formula (2) contribute to the treatment and prevention of susceptible infections, including hepatitis C (VHC) infection. A treatment for hosts infected with flashlights or plagueThis includes managing, where necessary, an effective amount of a host compound with a formula structure (1) or (2) or a pharmaceutically acceptable salt, or optionally produced in a pharmaceutically acceptable vehicle. Using a compound (1) or (2) with a formula structure or a salt acceptable for a drug or fromIt's also optional in making drugs to treat patients infected with Flavius or plague It's better that the infected host is human In one test, the formula (1) or (2) compound is manufactured with a second antiviral agent. The second antiviral agent was selected from the intervention group.ribavirina una interleuquina un inhibidor de proteasa NS3 un inhibidor de proteasa de cisteina un derivado de tiazolidina tiazolidina benzanilida fenantrenequinona un inhibidor de helicasa un inhibidor de polimerasa un an logo de nucle tido gliotoxina cerutenina fosforotiato oligodesoxinucle tidos antisentido inhibidores de la traducci n dependiente de IRES una Or a salt that can be used in medicine