Controlled release oral dosage form comprising 4 - (2 - Di - N - propilaminoetil) - 2 (3H) - indolona (Ropi - nirol) and use of said dosage form for the preparation of a drug

摘要

A controlled release oral dosage form comprising a therapeutically effective amount of 4 - (2 - Di - N - propilaminoetil) - 2 (3H) - indolona (ropinirole) or a Salt thereof,In which the average time taken for half the Peak plasma concentration (Cmax) 1 / 2) of ropinirole in vivo is less than 3 hours after Administration of the oral dosage form; and the average length of the anterior half of the Peak plasma concentration (1 / 2) Cmax of ropinirole in vivo is 7 to 13 hours.Use of such a dosage form for the development of a drug. These formulations for oral administration of ropinirole are useful in the treatment of diseases that can prevent or disturb sleep, particularly Restless legs syndrome (RLS); Pharmaceutical composition.