New tricyclic hydroxy carboxamides and tocolytic oxytocin receptor antagonists derived therefrom

摘要

"NEW HYDROXY TRICYCLIC CARBOXAMIDES AND TOCOLICY OTHOCOCINE RECEPTOR ANTAGONISTS FROM THE SAME". This invention provides novel tricyclic carboxamides that act as competitive oxytocin receptor antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods for their use in treating, inhibiting, suppressing or preventing premature labor, dysmenorrhea and endometritis, labor suppression. of delivery within the period of pregnancy before cesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and estrus synchronization in farm animals; and may be useful in preventing and treating central nervous system oxytocin system dysfunctions including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.