首页> 外国专利> Pharmaceutical composition, method for preparing same, methods for inhibiting the rate of precipitation of the solution agent in the GI tract, and for reducing inter-patient variability with respect to bioavailability and / or plasma concentrations of the agent, and use of a water soluble ether cellulose or an ester of a water soluble ether cellulose

Pharmaceutical composition, method for preparing same, methods for inhibiting the rate of precipitation of the solution agent in the GI tract, and for reducing inter-patient variability with respect to bioavailability and / or plasma concentrations of the agent, and use of a water soluble ether cellulose or an ester of a water soluble ether cellulose

机译:药物组合物,其制备方法,抑制溶液剂在胃肠道中的沉淀速率和降低患者之间关于药物的生物利用度和/或血浆浓度的变异性的方法,以及水溶性药物的用途醚纤维素或水溶性醚纤维素的酯

摘要

"PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING THE SAME, METHODS FOR INHIBITING THE RA TREATMENT AGENT PRECIPITATION RATE, AND FOR REDUCING INTER-PATIENT VARIABILITY WITH REGARD TO BIODISPONENT AND USE OF AGE / ADDITIONAL AGENCY A water-soluble ether cellulose or an ester of a water-soluble ether cellulose ". A pharmaceutical composition comprising 4- (3'-chloro-4'-fluoroanilino) -7-methoxy-6- (3-morpholine-propoxy) quinazoline or a pharmaceutically acceptable salt thereof (the Agent) and a cellulose ether water soluble or an ester of a water soluble ether cellulose. The water soluble ether cellulose or ester of a water soluble ether cellulose present in the composition inhibits the precipitation rate of the solution agent.
机译:“药物成分,制备方法相同,抑制RA治疗剂沉淀率的方法以及用于减少生物多样性以及使用年龄/附加年龄的人际差异的方法水溶性醚纤维素或水的酯可溶性醚纤维素”。药物组合物,其包含4-(3'-氯-4'-氟苯胺基)-7-甲氧基-6-(3-吗啉-丙氧基)喹唑啉或其药学上可接受的盐(所述试剂)和纤维素醚水溶性或水溶性醚纤维素的酯。组合物中存在的水溶性醚纤维素或水溶性醚纤维素的酯抑制溶液剂的沉淀速率。

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