Aqueous solution suitable for intranasal administration, process for preparation thereof, nasal release device, use of a method solution for inducing analgesia, uses of buprenorphine, and a pharmaceutical composition, and, pharmaceutical composition

摘要

"WATER SOLUTION SUITABLE FOR INTRANASAL ADMINISTRATION, PROCESS FOR THE PREPARATION OF THEREOF, NASAL RELEASE DEVICE, USE OF A SOLUTION, METHOD FOR ANALGESIA INDUCTION, BUPRENORPHINE USES, PHYSICAL COMPOSITION, COMPOSITION AND COMPOSITION. Aqueous formulations suitable for intranasal administration comprise buprenorphine or a physiologically acceptable salt or ester thereof and (a) a pectin having an esterification degree of less than 50%, (b) chitosan and a polyoxyethylene polyoxypropylene copolymer (poloxamer) or (c) chitosan and hydroxypropyl methylcellulose. Such formulations may induce rapid and prolonged analgesia when intranasally released to a patient. Buprenorphine or buprenorphine salt or ester may be released into the bloodstream to produce within 30 minutes a therapeutic plasma concentration of buprenorphine, C-ter ~ 0.2 ng / ml or greater that is maintained for a duration of T-maintenance. at least 2 hours.