Nucleic acid molecule encoding a muc-1 antigen, plasmid, protein, pharmaceutical composition, uses of a nucleic acid molecule and a protein, and, method for treating or preventing tumors or metastases.

摘要

"NUCLEIC ACID MOLECULE ENCODING AN ANTIGEN OF MUC-1, PLASMIDE, PROTEIN, PHARMACEUTICAL COMPOSITION, USES OF A NUCLEIC ACID MOLECLE AND A PROTEIN, AND, METHOD TO TREAT OR PRETENE OR PRETEN. The present invention relates to novel nucleic acid constructs usable in nucleic acid vaccination protocols for the treatment and prophylaxis of MUC-1 expressing tumors. Particularly, the nucleic acid is DNA and the DNA constructs comprise a gene encoding a MUC-1 derivative having less than 10 perfect repeating units. The invention further provides pharmaceutical compositions comprising said constructs, particularly pharmaceutical compositions adapted for particle mediated release, methods for their production, and their use in medicine. Novel nucleic acid encoded proteins and pharmaceutical compositions containing them are also provided.